Optimizing Prevention of HIV and Unplanned Pregnancy in Discordant African Couples

Conception in Hiv-discordant Couples

Pregnancy and HIV transmission among HIV-discordant couples in a clinical trial in Kisumu, Kenya.

OBJECTIVES A large proportion of new HIV infections in sub-Saharan Africa occur in stable HIV-discordant partnerships. In some couples, the strong desire to conceive a child may lead to risky behaviour despite knowledge of discordant serostatus. Our objective was to compare HIV transmission between discordant couples who did and did not conceive during participation in a clinical trial. METHO...

Risk of HIV transmission in discordant couples.

270 www.thelancet.com Vol 372 July 26, 2008 confi dent that there had been no breach of research integrity on the part of the authors, and that every eff ort had been made to achieve consensus on the submitted manuscript. The Lancet also sought advice from the Committee on Publication Ethics (COPE), who agreed with the journal’s suggestion to invite Phadke to write a Correspondence letter for p...

Missed Opportunities for HIV Infection Prevention in HIV Sero-Discordant and X-Negative Concordant Couples

Antiretroviral therapy for prevention of HIV transmission in HIV-discordant couples.

BACKGROUND Antiretroviral drugs have been shown to reduce risk of mother-to-child transmission of human immunodeficiency virus (HIV) and are also widely used for post-exposure prophylaxis for parenteral and sexual exposures. Observational data, ecological studies and models suggest that sexual transmission may be lower in couples in which one partner is infected with HIV and the other is not an...